Norwich (pop. 7,190 per 2010 census), the seat of Chenango County, was once an economic powerhouse. It was a regional rail center until the mid-twentieth century. In addition, the company best known as Norwich Pharmaceuticals was founded here in 1887. In 1893, the firm introduced Unguentine as a surgical antiseptic. The product later became popular among consumers as a topical antiseptic. In 1901, Norwich created the liquid antacid later named Pepto-Bismol. Unguentine and Pepto-Bismol became hugely popular consumer products; Pepto-Bismol remains so today. Norwich Pharmaceuticals was acquired by Morton International in 1969, then sold to Procter & Gamble in 1982. Its operations in Norwich dwindled, leaving the community economically adrift for some time. Its economy has since partially recovered; today it hosts the headquarters of NBT Bank, a regional financial institution; and Chobani, the national marketer of Greek yogurt.
The community's onetime wealth is reflected in the Chenango County Courthouse District. The District encompasses much of downtown Norwich and includes forty-five contributing buildings and two parks. Noteworthy buildings include Chenango County Courthouse (1837), First Baptist Church (1845), County Clerk's office (1852), Maurice Ireland Building (1880), Erie-Lackawanna Railroad Depot (1902), City Hall (1903), Sheriff's Office (1905), and the Old Norwich Hotel (undated). The District also includes a historic Post Office (1932), which is listed separately. The Chenango County Courthouse District was added to the National Register of Historic Places in 1975.
On February 26, 1885, Robert Green Ingersoll, the nation's premier freethought orator, delivered a lecture in Norwich. The building in which he spoke, the Breese Opera House, is a contributing building of the Courthouse District and still stands today.